Starsem conducts launches of the Soyuz and modernized Soyuz from the Baikonur Cosmodrome, one of the world's busiest launch sites. The Cosmodrome is used by Soyuz for a variety of missions, including human space flights.

Soyuz missions use the Cosmodrome's proven infrastructure, with two launch pads dedicated to Soyuz missions. Areas for customers and spacecraft ground support equipment are located at the launch sites and in the control bunker. Starsem's new state-of-the-art Payload Processing Facilities with Class 100,000 (1158 m2) clean rooms are used for satellite integration, fueling and checkout services.

The operational capability of these facilities has been demonstrated during the pre-launch operations of Starsem's twelve flights. The launch pad and related facilities have been upgraded to provide launch capability with the modernized Soyuz launch vehicle as well as to meet user requirements.

Starsem was also a partner in building the Sputnik Hotel, a facility situated close to the Cosmodrome in the city of Baikonur. This world-class, 125-room facility is available for Starsem customers and provides an optimal environment for both work and recreation. Transportation is readily available to and from the Cosmodrome.

The Cosmodrome is situated in the Republic of Kazakhstan in central Asia, between 45° and 46° North latitude and 63° East longitude. An international agreement forged between Russia and Kazakhstan to use the Cosmodrome until 2020 ensures the long-term operation of Soyuz from the Baikonur Cosmodrome.